CSIR NET Life Science Unit 11 MCQs with Answers

Here below are 15 core Bioinformatics and Computational Biology topics across five parts. Choose Easy, Medium or Difficult for each topic to practise 15 questions per level. Answers show the correct option and explanation immediately.

Part 1: Topics 1–3

1. Biological Databases

15 questions per difficulty level · Select a level

2. Sequence Formats and Retrieval

15 questions per difficulty level · Select a level

3. Pairwise Sequence Alignment

15 questions per difficulty level · Select a level

Part 2: Topics 4–6

4. Scoring Matrices and BLAST

15 questions per difficulty level · Select a level

5. Multiple Sequence Alignment

15 questions per difficulty level · Select a level

6. Phylogenetic Analysis

15 questions per difficulty level · Select a level

Part 3: Topics 7–9

7. Genome Assembly and Annotation

15 questions per difficulty level · Select a level

8. Next-Generation Sequencing

15 questions per difficulty level · Select a level

9. Transcriptomics and RNA-seq

15 questions per difficulty level · Select a level

Part 4: Topics 10–12

10. Proteomics and Mass Spectrometry

15 questions per difficulty level · Select a level

11. Protein Structure Prediction

15 questions per difficulty level · Select a level

12. Molecular Docking

15 questions per difficulty level · Select a level

Part 5: Topics 13–15

13. Systems Biology and Networks

15 questions per difficulty level · Select a level

14. Biostatistics for Bioinformatics

15 questions per difficulty level · Select a level

15. Machine Learning in Bioinformatics

15 questions per difficulty level · Select a level

Frequently Asked Questions

What is the difference between global and local sequence alignment?

Global alignment attempts to align sequences end to end; local alignment identifies the highest-scoring matching subsequences.

What does an E-value represent in a BLAST result?

It estimates the number of alignments with an equivalent or better score expected by chance under the search model.

Why are substitution matrices used in protein alignment?

They score amino acid substitutions based on evolutionary or empirical patterns of similarity.

How does a FASTA file differ from a FASTQ file?

FASTA stores sequence identifiers and sequences; FASTQ additionally stores per-base quality scores.

What is the difference between sensitivity and specificity in a classifier?

Sensitivity measures detection of true positives; specificity measures correct identification of true negatives.

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